Concerning neuroprotective therapy for Parkinson's disease.

نویسندگان

  • R J Uitti
  • Z K Wszolek
چکیده

Studying potential neuroprotective therapy for Parkinson's disease is conceptually problematic because of the heterogenous nature of the Parkinson's syndrome and complexities in operational definitions for neuroprotection. The current literature concerning neuroprotection provides no convincing evidence of any treatment as definitively neuroprotective in Parkinson's disease. Recent clinical trials and novel trial designs are reviewed that may identify meaningful therapy, resulting in maintenance of neurological function and quality of life for persons with Parkinson's disease.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Neuroprotective effects of vitamin E on the early unilateral model of Parkinson\'s disease in the rat: A behavioral and tract-tracing study

  Parkinson's disease (PD) is a human neurodegenerative disorder that is associated with a massive and progressive degeneration of the dopaminergic neurons of the substantia nigra. There is strong evidence that oxidative stress participates in the etiology of PD. Therefore, we designed this study to investigate the neuroprotective activity of vitamin E, a free radical scavenger in the unilatera...

متن کامل

Neuroprotective effect of caffeine in an early model of Parkinson's disease in rat: behavioral and histochemical evidence

Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting 1 to 3% of individuals over the age of 65 years. Both retrospective and prospective epidemiological studies have consistently demonstrated an inverse association between coffee consumption and PD. This study was designed to investigate the beneficial effect of caffeine in an early model of PD. For this purpo...

متن کامل

Neuroprotective effect of caffeine in an early model of Parkinson's disease in rat: behavioral and histochemical evidence

Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting 1 to 3% of individuals over the age of 65 years. Both retrospective and prospective epidemiological studies have consistently demonstrated an inverse association between coffee consumption and PD. This study was designed to investigate the beneficial effect of caffeine in an early model of PD. For this purpo...

متن کامل

Evaluation of neuroprotective effects of cobalamin (vitamin B12) in Parkinson's disease - Investigation of molecular mechanisms

‌Background & objectives: Parkinson's disease is one of the most common neurodegenerative diseases that its prevalence has increased in recent years. Although many efforts have been made to treat this disease, so far, no therapeutic approach has been found that can stop the destruction of dopaminergic cells in the substantia nigra. The aim of the present study was to investigate the effect of v...

متن کامل

Neuroprotection by dopamine agonists.

Research on Parkinson's disease has led to new hypotheses concerning the mechanisms of neurodegeneration and to the development of neuroprotective agents. Recent findings of impaired mitochondrial function, altered iron metabolism and increased lipid peroxidation in the substantia nigra of parkinsonian patients emphasize the significance of oxidative stress and free radical formation in the pat...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of neural transmission. Supplementum

دوره 70  شماره 

صفحات  -

تاریخ انتشار 2006